(Liminalities, Cycle 1, Part 2)
In my novelette “Teeth” — first published at Thomas Ligotti Online, then in The Children of Cthulhu, and then in expanded form in my Dark Awakenings — there’s a scene where the narrator reads a notebook filled with ruminations on the convergence of philosophy and religion with cosmic horror, all interwoven with an examination of the same issues in the context of quantum physics. He’s a graduate student in philosophy, but the reading of these things initiates a transformative change in his psychic constitution and gives him a different sort of philosophical education than the one he had previously pursued.
He summarizes the notebook’s scientific content and import like this:
The mathematical work was beyond me, but from his text notes I could gather enough to grasp the bare essence of the matter, which had something to do with the philosophical implications of quantum mechanics. I read that the equations used in this science are straightforward and uncontested in terms of their practical applications, as attested by everything from television to the hydrogen bomb, but that no satisfactory explanation for their meaning, their overall implications at the macroscopic level of existence, had yet been established. On the subatomic level, I read, particles flash into and out of existence for no discernible reason, and the behavior of any single particle is apparently arbitrary and usually unpredictable. If there is a cause or “purpose” behind this behavior, then it is one that the human mind is, to all appearances, structurally prevented from comprehending. In other words, for all we know, the fundamental ruling principles at the most basic level of physical reality may well be what our minds and languages must necessarily label “chaos” and “madness.” 
When I first wrote those lines in the mid-1990s, I was enwrapped in a pattern of inner and outer events and circumstances — personal, professional, psychological, spiritual — that seemed either shriekingly meaningless or evilly intended, and I was utterly unable to decide which possibility, nihilism or a malevolent cosmos, seemed more likely, and also, pointedly, which one seemed worse. And amid the indecision, regardless of the causes, I was suffering.